Letitia Wright, as T'Challa's sister Shuri, and Angela Bassett, as Queen Ramonda, struggle to fill the king's shoes. Also starring are Lupita Nyong'o, Danai Gurira and Winston Duke.
The original "Black Panther," the first major black superhero movie, became a cultural phenomenon, with a $202 million opening and a best-picture Oscar nomination.
Far, far behind in second place this weekend was Warner Bros.' 'Black Adam," at $8.6 million -- not even one-twentieth the 'Wakanda' total. The Dwayne Johnson vehicle, a spinoff from 2019's "Shazam!," has now taken in $141.1 million domestically.
Universal's rom-com 'Ticket to Paradise,' powered by mega-stars Julia Roberts and George Clooney, managed to defy the superhero trend to place third, taking in $6.1 million in its fourth week out.
A family-friendly film, Sony's live-action/computer animated musical comedy 'Lyle, Lyle, Crocodile,' placed fourth at $3.2 million.
And Paramount's horror movie 'Smile' continued to find viewers in its seventh week out, coming in fifth. With an estimated take of $2.3 million for the Friday-through-Sunday period, its domestic total bumped up to $102 million.
Rounding out the top 10 were:
"Prey for the Devil" ($2.0 million)
"The Banshees of Inisherin" ($1.7 million)
"One Piece Film: Red" ($1.4 million)
"Till" ($618,000)
"Armageddon Time" ($352,000)